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Recent Publications

Selected publications

  1. Iga T, Kobayashi H, Kusumoto D, Sanosaka T, Fujita N, Tai-Nagara I, Ando T, Takahashi T, Matsuo K, Hozumi K, Ito K, Ema M, Miyamoto T, Matsumoto M, Nakamura M, Okano H, Shibata S, Kohyama J, Kim KK, *Takubo K, *Kubota Y. Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis Nat Cell Biol 2023 25(10):1415-1425, 2023. pubmed
  2. Matsubara T, Iga T, Sugiura Y, Kusumoto D, Sanosaka T, Tai-Nagara I, Takeda N, Fong GH, Ito K, Ema M, Okano H, Kohyama J, Suematsu M, *Kubota Y. Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice J Exp Med 4; 219(4): e20211789, 2022. pubmed
  3. Ando T, Tai-Nagara I, Sugiura Y, Kusumoto D, Okabayashi K, Kido Y, Sato K, Saya H, Navankasattusas S, Li DY, Suematsu M, Kitagawa Y, Seiradake E, *Yamagishi S, *Kubota Y. Tumor-specific inter-endothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness. J Clin Invest; 2022:e153626, 2022. pubmed
  4. Tai-Nagara I, Hasumi Y, Kusumoto D, Hasumi H, Okabe K, Ando T, Matsuzaki F, Itoh F, Saya H, Liu C, Li W, Mukouyama YS, Marston Linehan W, Liu X, Hirashima M, Suzuki Y, Funasaki S, Satou Y, Furuya M, *Baba M, *Kubota Y. Nat Commun 11(1):6314, 2020. pubmed
  5. Yoshikawa Y, Yamada T, Tai-Nagara I, Okabe K, Kitagawa Y, Ema M and *Kubota Y. Developmental regression of hyaloid vasculature is triggered by neurons. J Exp Med 213(7): 1175-83, 2016.pubmed
  6. Okabe K, Kobayashi S, Yamad T, Kurihara T, Tai-Nagara I, Miyamoto T, Mukouyama YS, Sato TN, Suda T, Ema M and *Kubota Y. Neurons limit angiogenesis by titrating VEGF in retina. Cell 159: 584-596 2014. pubmed
  7. Okuno Y, Nakamura-Ishizu A, Otsu K, Suda T and *Kubota Y. Pathological neoangiogenesis depends on oxidative stress regulation by ATM. Nat Med 18(8): 1208–1216, 2012. pubmed
  8. *Kubota Y, Takubo K, Shimizu T, Ohno H, Kishi K, Shibuya M, Saya H and *Suda T. M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J Exp Med 206: 1089-102, 2009. pubmed
  9. *Kubota Y, Hirashima M, Kishi K, Stewart CL and *Suda T. Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice. J Clin Invest 118(7): 2393-2403, 2008. pubmed



2024

  1. Iga T, Kobayashi H, Kusumoto D, Sanosaka T, Fujita N, Tai-Nagara I, Ando T, Takahashi T, Matsuo K, Hozumi K, Ito K, Ema M, Miyamoto T, Matsumoto M, Nakamura M, Okano H, Shibata S, Kohyama J, Kim KK, *Takubo K, *Kubota Y. Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis Nat Cell Biol 2023 25(10):1415-1425. pubmed /37798545/　doi: 10.1038/s41556-023-01240-7.
  2. Fujiwara T, Takeda N, Hara H, Ishii S, Numata G, Tokiwa H, Katoh M, Maemura S, Suzuki T, Takiguchi H, Yanase T, Kubota Y, Nomura S, Hatano M, Ueda K, Harada M, Toko H, Takimoto E, Akazawa H, Morita H, Nishimura S, Komuro I. PGC-1α-mediated angiogenesis prevents pulmonary hypertension in mice. JCI Insight 2023 8(17): e162632. pubmed /37681410/ doi: 10.1172/jci.insight.162632.
  3. Akiyama T, Sadahiro T, Yamada Y, Fujita R, Abe Y, Nakano K, Honda S, Ema M, Kubota Y, Sakai S, Hizawa N, *Ieda M. Flk1 Deficiency and Hypoxia Synergistically Promote Endothelial Dysfunction, Vascular Remodeling, and Pulmonary Hypertension. Arterioscler Thromb Vasc Biol. 2023 pubmed /37534464/ doi: 10.1161/ATVBAHA.123.319266.
  4. Cao X, Li T, Xu B, Ding K, Li W, Shen B, Chu M, Zhu D, Rui L, Shang Z, Li X, Wang Y, Zheng S, Alitalo K, Liu G, Tang J, Kubota Y, *He Y. Endothelial TIE1 Restricts Angiogenic Sprouting to Coordinate Vein Assembly in Synergy With Its Homologue TIE2. Arterioscler Thromb Vasc Biol. 2023 43(8):e323-e338. pubmed /37317851/ doi: 10.1161/ATVBAHA.122.318860.
  5. Yamashiro Y, Ramirez K, Nagayama K, Hattori N, Liu YY, Matsunaga S, Tomita S, Kubota Y, *Yanagisawa H. Partial endothelial-to-mesenchymal transition mediated by HIF-induced CD45 in neointima formation upon carotid artery ligation. Cardiovasc Res. 2023;　19(7):1606-1618. pubmed /36537041/ doi: 10.1093/cvr/cvac190.
  6. Morita M, Yoneda A, Tokunoh N, Masaki T, Shirakura K, Kinoshita M, Hashimoto R, Shigesada N, Takahashi J, Tachibana M, Tanaka S, Obana M, Hino N, Ikawa M, Tsujikawa K, Ono C, Matsuura Y, Kidoya H, Takakura N, Kubota Y, Doi T, Takayama K, Yoshioka Y, Fujio Y, *Okada Y. Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models. Proc Natl Acad Sci U S A. 2023;　20(3):　2213317120. pubmed /36634143/ doi: 10.1073/pnas.2213317120.

2023

  1. Iga T, Kobayashi H, Kusumoto D, Sanosaka T, Fujita N, Tai-Nagara I, Ando T, Takahashi T, Matsuo K, Hozumi K, Ito K, Ema M, Miyamoto T, Matsumoto M, Nakamura M, Okano H, Shibata S, Kohyama J, Kim KK, *Takubo K, *Kubota Y. Spatial heterogeneity of bone marrow endothelial cells unveils a distinct subtype in the epiphysis Nat Cell Biol 2023 25(10):1415-1425. pubmed /37798545/　doi: 10.1038/s41556-023-01240-7.
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  2. Fujiwara T, Takeda N, Hara H, Ishii S, Numata G, Tokiwa H, Katoh M, Maemura S, Suzuki T, Takiguchi H, Yanase T, Kubota Y, Nomura S, Hatano M, Ueda K, Harada M, Toko H, Takimoto E, Akazawa H, Morita H, Nishimura S, Komuro I. PGC-1α-mediated angiogenesis prevents pulmonary hypertension in mice. JCI Insight 2023 8(17): e162632. pubmed /37681410/ doi: 10.1172/jci.insight.162632.
  3. Akiyama T, Sadahiro T, Yamada Y, Fujita R, Abe Y, Nakano K, Honda S, Ema M, Kubota Y, Sakai S, Hizawa N, *Ieda M. Flk1 Deficiency and Hypoxia Synergistically Promote Endothelial Dysfunction, Vascular Remodeling, and Pulmonary Hypertension. Arterioscler Thromb Vasc Biol. 2023 pubmed /37534464/ doi: 10.1161/ATVBAHA.123.319266.
  4. Cao X, Li T, Xu B, Ding K, Li W, Shen B, Chu M, Zhu D, Rui L, Shang Z, Li X, Wang Y, Zheng S, Alitalo K, Liu G, Tang J, Kubota Y, *He Y. Endothelial TIE1 Restricts Angiogenic Sprouting to Coordinate Vein Assembly in Synergy With Its Homologue TIE2. Arterioscler Thromb Vasc Biol. 2023 43(8):e323-e338. pubmed /37317851/ doi: 10.1161/ATVBAHA.122.318860.
  5. Yamashiro Y, Ramirez K, Nagayama K, Hattori N, Liu YY, Matsunaga S, Tomita S, Kubota Y, *Yanagisawa H. Partial endothelial-to-mesenchymal transition mediated by HIF-induced CD45 in neointima formation upon carotid artery ligation. Cardiovasc Res. 2023;　19(7):1606-1618. pubmed /36537041/ doi: 10.1093/cvr/cvac190.
  6. Morita M, Yoneda A, Tokunoh N, Masaki T, Shirakura K, Kinoshita M, Hashimoto R, Shigesada N, Takahashi J, Tachibana M, Tanaka S, Obana M, Hino N, Ikawa M, Tsujikawa K, Ono C, Matsuura Y, Kidoya H, Takakura N, Kubota Y, Doi T, Takayama K, Yoshioka Y, Fujio Y, *Okada Y. Upregulation of Robo4 expression by SMAD signaling suppresses vascular permeability and mortality in endotoxemia and COVID-19 models. Proc Natl Acad Sci U S A. 2023;　20(3):　2213317120. pubmed /36634143/ doi: 10.1073/pnas.2213317120.

2022

  1. Namiki J, Suzuki S, Shibata S, Kubota Y, Kaneko N, Yoshida K, Yamaguchi R, Matsuzaki Y, Masuda T, Ishihama Y, Sawamoto K, *Okano H. Chitinase-like protein 3: A novel niche factor for mouse neural stem cells. Stem Cell Reports. 2022; 17(12):2704-2717. pubmed/36368330/ doi: 10.1016/j.stemcr.2022.10.012.
  2. Furuuchi R, Shimizu I, Yoshida Y, Katsuumi G, Suda M, Kubota Y, Walsh K, *Minamino T. Endothelial SIRT-1 has a critical role in the maintenance of capillarization in brown adipose tissue. iScience. 2022; 25(11):105424. pubmed /36388988/ doi: 10.1016/j.isci.2022.105424. eCollection 2022
  3. Watanabe C, Shibuya H, Ichiyama Y, Okamura E, Tsukiyama-Fujii S, Tsukiyama T, Matsumoto S, Matsushita J, Azami T, Kubota Y, Ohji M, Sugiyama F, Takahashi S, Mizuno S, Tamura M, Mizutani KI, *Ema M. Essential Roles of Exocyst Complex Component 3-like 2 on Cardiovascular Development in Mice. Life (Basel). 2022; 12(11):1730. pubmed/36362885/ doi: 10.3390/life12111730.
  4. Takahashi K, Abe K, Kubota SI, Fukatsu N, Morishita Y, Yoshimatsu Y, Hirakawa S, Kubota Y, Watabe T, Ehata S, Ueda HR, Shimamura T, Miyazono K. An analysis modality for vascular structures combining tissue-clearing technology and topological data analysis. Nat Commun. 2022 ;13(1):5239. pubmed /36097010/ doi: 10.1038/s41467-022-32848-2.
  5. Zhang Y, Jeong H, Mori K, Ikeda SI, Shoda C, Miwa Y, Nakai A, Chen J, Ma Z, Jiang X, Torii H, Kubota Y, Negishi K, Kurihara T, Tsubota K. Vascular endothelial growth factor from retinal pigment epithelium is essential in choriocapillaris and axial length maintenance. PNAS Nexus. 2022;1(4): pgac166. pubmed /36714840/ doi: 10.1093/pnasnexus/pgac166.
  6. *Yokomizo T, Ideue T, Morino-Koga S, Tham CY, Sato T, Takeda N, Kubota Y, Kurokawa M, Komatsu N, Ogawa M, Araki K, Osato M, *Suda T. Independent origins of fetal liver haematopoietic stem and progenitor cells. Nature. 2022; 609(7928): 779-784. doi: 10.1038/s41586-022-05203-0. pubmed /36104564/
  7. Yoshida Y, Shimizu I, Shimada A, Nakahara K, Yanagisawa S, Kubo M, Fukuda S, Ishii C, Yamamoto H, Ishikawa T, Kano K, Aoki J, Katsuumi G, Suda M, Ozaki K, Yoshida Y, Okuda S, Ohta S, Okamoto S, Minokoshi Y, Oda K, Sasaoka T, Abe M, Sakimura K, Kubota Y, Yoshimura N, Kajimura S, Zuriaga M, Walsh K, Soga T, *Minamino T. Brown adipose tissue dysfunction promotes heart failure via a trimethylamine N-oxide-dependent mechanism. Sci Rep. 2022;12(1):14883. pubmed /36050466/ doi: 10.1038/s41598-022-19245-x.
  8. Matsubara T, Iga T, Sugiura Y, Kusumoto D, Sanosaka T, Tai-Nagara I, Takeda N, Fong GH, Ito K, Ema M, Okano H, Kohyama J, Suematsu M, *Kubota Y. Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice J Exp Med 4; 219(4): e20211789. pubmed/35319724/ doi: 10.1084/jem.20211789.
  9. Harada Y, *Sujino T, Miyamoto K, Nomura E, Yoshimatsu Y, Tanemoto S, Umeda S, Ono K, Mikami Y, Nakamoto N, Takabayashi K, Hosoe N, Ogata H, Ikenoue T, Hirao A, Kubota Y, Kanai T. Intracellular metabolic adaptation of intraepithelial CD4+CD8αα+ T lymphocytes. iScience;25(4): 104021, 2022. pubmed /35313689/ doi: 10.1016/j.isci.2022.104021.
  10. Namiguchi K, Sakaue T, Okazaki M, Kanno K, Komoda Y, Shikata F, Kurata M, Ota N, Kubota Y, Kurobe H, Nishimura T, Masumoto J, Higashiyama S, *Izutani H. Unique Angiogenesis From Cardiac Arterioles During Pericardial Adhesion Formation. Front Cardiovasc Med; 8: 761591, 2022. pubmed/35187100/ doi: 10.3389/fcvm.2021.761591.
  11. Kanki Y, Muramatsu M, Miyamura Y, Kikuchi K, Higashijima Y, Nakaki R, Suehiro JI, Sasaki Y, Kubota Y, Koseki H, Morioka H, Kodama T, Nakao M, Kurotaki D, Aburatani H, Minami T. Bivalent-histone-marked immediate-early gene regulation is vital for VEGF-responsive angiogenesis. Cell Rep ;38(6):110332. pubmed /35139389/doi: 10.1016/j.celrep.2022.110332.
  12. Ando T, Tai-Nagara I, Sugiura Y, Kusumoto D, Okabayashi K, Kido Y, Sato K, Saya H, Navankasattusas S, Li DY, Suematsu M, Kitagawa Y, Seiradake E, *Yamagishi S, *Kubota Y. Tumor-specific inter-endothelial adhesion mediated by FLRT2 facilitates cancer aggressiveness. J Clin Invest; 2022:e153626, 2022. pubmed /35104247/ doi: 10.1172/JCI153626.
    press release (Japanese)
    nikkeibp (Japanese)
  13. Karaman S, Paavonsalo S, Heinolainen K, Lackman MH, Ranta A, Hemanthakumar KA, Kubota Y, *Alitalo K.　Interplay of vascular endothelial growth factor receptors in organ-specific vessel maintenance. J Exp Med; 219(3):e20210565, 2022. pubmed /35050301/ doi: 10.1084/jem.20210565.
  14. Kido Y, Ando T, Iga T, Ema M, *Kubota Y, *Tai-Nagara I. Genetic deletion of Vegfr2 in endothelial cells leads to immediate disruption of tumor vessels and aggravation of hypoxia. Am J Pathol;192(2):379-388. pubmed /34861214/ doi: 10.1016/j.ajpath.2021.11.003.
    Issue cover

2021

  1. Endo Y, Asanuma D, Namiki S, Sugihara K, Hirose K, Uemura A, Kubota Y, Miura T. Quantitative modeling of regular retinal microglia distribution. Sci Rep 11(1):22671. pubmed /34811401/ doi: 10.1038/s41598-021-01820-3.
  2. Fujiwara T, Takeda N, Hara H, Ishii S, Numata G, Tokiwa H, Maemura S, Suzuki T, Takiguchi H, Kubota Y, Seo K, Sakata A, Nomura S, Hatano M, Ueda K, Harada M, Toko H, Takimoto E, Akazawa H, Nishimura S, Komuro I. Three-Dimensional Visualization of Hypoxia-Induced Pulmonary Vascular Remodeling in Mice. Circulation 144(17):1452-1455, 2021. pubmed/34694894/ doi: 10.1161/CIRCULATIONAHA.121.056219.
  3. Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS, Gonzalez-Nuñez M, Austin-Williams SN, Cooper D, Vázquez-Martínez L, Fu T, De Rossi G, Golding M, Voisin MB, Boulanger CM, Kubota Y, Muller WA, Tooze SA, Nightingale TD, Collinson L, Perretti M, Aksoy E, Nourshargh S. Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation. Immunity 54(9):1989-2004, 2021. pubmed /34363750/ doi: 10.1016/j.immuni.2021.07.012.
  4. Yoshida Y, Yamada A, Akimoto Y, Abe K, Matsubara S, Hayakawa J, Tanaka J, Kinoshita M, Kato T, Ogata H, Sakashita A, Mishima K, Kubota Y, Kawakami H, Kamijo R, Iijima T. Cdc42 has important roles in postnatal angiogenesis and vasculature formation. Dev Biol 477:64-69, 2021. pubmed/34019880
  5. Li W, Liu C, Burns N, Hayashi J, Yoshida A, Sajja A, González-Hernández S, Gao JL, Murphy PM, Kubota Y, Zou YR, Nagasawa T, Mukouyama YS. Alterations in the spatiotemporal expression of the chemokine receptor CXCR4 in endothelial cells cause failure of hierarchical vascular branching. Dev Biol 477:70-84, 2021. pubmed/34015362
  6. Andrade J, Shi C, Costa ASH, Choi J, Kim J, Doddaballapur A, Sugino T, Ong YT, Castro M, Zimmermann B, Kaulich M, Guenther S, Wilhelm K, Kubota Y, Braun T, Koh GY, Grosso AR, Frezza C, Potente M. Control of endothelial quiescence by FOXO-regulated metabolites. Nat Cell Biol 23(4):413-423, 2021. pubmed/33795871
  7. Sorimachi Y, Karigane D, Ootomo Y, Kobayashi H, Morikawa T, Otsu K, Kubota Y, Okamoto S, Goda N, Takubo K. p38α plays differential roles in hematopoietic stem cell activity dependent on aging contexts. J Biol Chem 296:100563, 2021. pubmed/33745970
  8. Ichijo R, Kabata M, Kidoya H, Muramatsu F, Ishibashi R, Abe K, Tsutsui K, Kubo H, Iizuka Y, Kitano S, Miyachi H, Kubota Y, Fujiwara H, Sada A, Yamamoto T, Toyoshima F. Vasculature-driven stem cell population coordinates tissue scaling in dynamic organs. Sci Adv 7(7):eabd2575, 2021. pubmed/33568475
  9. Ichiyama Y, Obata S, Saishin Y, Sawada O, Kakinoki M, Sawada T, Kubota Y, Ohji M. The systemic antiangiogenic effect of intravitreal aflibercept injection in a mouse model of retinopathy of prematurity. FASEB J 35(3):e21390, 2021. pubmed/33566381

2020

  1. Tai-Nagara I, Hasumi Y, Kusumoto D, Hasumi H, Okabe K, Ando T, Matsuzaki F, Itoh F, Saya H, Liu C, Li W, Mukouyama YS, Marston Linehan W, Liu X, Hirashima M, Suzuki Y, Funasaki S, Satou Y, Furuya M, *Baba M, *Kubota Y. Nat Commun 11(1):6314, 2020. pubmed/33298956
    Editors’ Highlights
    Press release (Japanse)
    Nikkei online (Japanese)
  2. Brash JT, Bolton RL, Rashbrook VS, Denti L, Kubota Y, *Ruhrberg C. Tamoxifen-Activated Cre Impairs Retinal Angiogenesis Independently of Gene Deletion. Circ Res 127(6):849-850, 2020. pubmed/32635822
  3. Ma X, Uchida Y, Wei T, Liu C, Adams RH, Kubota Y, Gutkind JS, Mukouyama YS, *Adelstein RS. Nonmuscle Myosin 2 Regulates Cortical Stability during Sprouting Angiogenesis. Mol Biol Cell 31(18):1974-1987, 2020. pubmed/32583739
  4. Takahashi M, Misaki M, Shibata S, Iga T, Shindo T, Tai-Nagara I, Hirata A, Ogawa M, Miyamoto T, Nakagawa T, Ema M, Ichiyama Y, Shima DT, Hozumi K, Nishimura S, *Kubota Y. Macrophages fine-tune pupil shape during development. Dev Biol 464(2):137-144, 2020. pubmed/32565279
  5. Niimi K, Kohara M, Sedoh E, Fukumoto M, Shibata S, Sawano T, Tashiro F, Miyazaki S, Kubota Y, Miyazaki JI, *Inagaki S, *Furuyama T. FOXO1 regulates developmental lymphangiogenesis by upregulating CXCR4 in the mouse-tail dermis. Development 147(2): dev181545, 2020. pubmed/31852686

2019

  1. Ueda T, Yokota T, Okuzaki D, Uno Y, Mashimo T, Kubota Y, Sudo T, Ishibashi T, Shingai Y, Doi Y, Ozawa T, Nakai R, Tanimura A, Ichii M, Ezoe S, Shibayama H, Oritani K, Kanakura Y. Endothelial Cell-Selective Adhesion Molecule Contributes to the Development of Definitive Hematopoiesis in the Fetal Liver. Stem Cell Reports 13(6):992-1005, 2019. pubmed /31813828
  2. Niimi K, Adachi Y, Ishikawa H, Yamaguchi W, Kubota Y, Inagaki S, Furuyama T. Endothelial specific deletion of FOXO1 alters pericyte coverage in the developing retina. Biochem Biophys Res Commun 520(2):304-310, 2019. pubmed/31601422
  3. Okabe K, Fukada H, Tai-Nagara I, Ando T, Honda T, Nakajima K, Takeda N, Fong GH, Ema M, *Kubota Y. Neuron-derived VEGF contributes to cortical and hippocampal development independently of VEGFR1/2-mediated neurotrophism. Dev Biol S0012-1606(19)30536-6, 2019. pubmed/31790655
  4. Niimi K, Adachi Y, Ishikawa H, Yamaguchi W, Kubota Y, Inagaki S, Furuyama T. Endothelial specific deletion of FOXO1 alters pericyte coverage in the developing retina. Biochem Biophys Res Commun 520(2):304-310, 2019. pubmed/31601422
  5. Ono S, Egawa G, Nomura T, Kitoh A, Dainichi T, Otsuka A, Nakajima S, Amagai M, Matsumoto F, Yamamoto M, Kubota Y, Takai T, Honda T, Kabashima K.　Nat Commun 10(1): 4432, 2019. pubmed/31570755
  6. Zahra FT, Sajib MS, Ichiyama Y, Akwii RG, Tullar PE, Cobos C, Minchew SA, Doçi CL, Zheng Y, Kubota Y, Gutkind JS, Mikelis CM. Endothelial RhoA GTPase is essential for in vitro endothelial functions but dispensable for physiological in vivo angiogenesis. Sci Rep 9(1):116662019. pubmed /31406143
  7. Yokoyama M, Shimizu I, Nagasawa A, Yoshida Y, Katsuumi G, Wakasugi T, Hayashi Y, Ikegami R, Suda M, Ota Y, Okada S, Fruttiger M, Kobayashi Y, Tsuchida M, Kubota Y, Minamino T. p53 plays a crucial role in endothelial dysfunction associated with hyperglycemia and ischemia. J Mol Cell Cardiol 129:105-117, 2019. pubmed/30790589
  8. Kim J, Park JR, Choi J, Park I, Hwang Y, Bae H, Kim Y, Choi W, Yang JM, Han S, Chung TY, Kim P, Kubota Y, Augustin HG, Oh WY, Koh GY. Tie2 activation promotes choriocapillary regeneration for alleviating neovascular age-related macular degeneration. Sci Adv 5(2), 2019. pubmed/30788433
  9. Kim YH, Choi J, Yang MJ, Hong SP, Lee CK, Kubota Y, Lim DS, Koh GY. A MST1-FOXO1 cascade establishes endothelial tip cell polarity and facilitates sprouting angiogenesis. Nat Commun 10(1):838, 2019. pubmed/30783090
  10. Naito H, Iba T, Wakabayashi T, Tai-Nagara I, Suehiro JI, Jia W, Eino D, Sakimoto S, Muramatsu F, Kidoya H, Sakurai H, Satoh T, Akira S, Kubota Y, Takakura N. TAK1 Prevents Endothelial Apoptosis and Maintains Vascular Integrity. Dev Cell 48(2):151-166, 2019. pubmed/30639056

2018

  1. Lee SJ, Lee CK, Kang S, Park I, Kim YH, Kim SK, Hong SP, Bae H, He Y, Kubota Y, *Koh GY. Angiopoietin-2 exacerbates cardiac hypoxia and inflammation after myocardial infarction. J Clin Invest 128: 5018-5033, 2018. pubmed/30295643
  2. Si S, Nakajima-Takagi Y, Iga T, Tsuji M, Hou L, Oshima M, Koide S, Saraya A, Yamazaki S, Takubo K, Kubota Y, Minamino T, *Iwama A. Hematopoietic insults damage bone marrow niche by activating p53 in vascular endothelial cells. Exp Hematol 63: 41-51.e1. 2018. pubmed/29709619

2017

  1. Kurotsu S, Osakabe R, Isomi M, Tamura F, Sadahiro T, Muraoka N, Kojima H, Haginiwa S, Tani H, Nara K, Kubota Y, Ema M, Fukuda K, Suzuki T, *Ieda M. Distinct expression patterns of Flk1 and Flt1 in the coronary vascular system during development and after myocardial infarction. Biochem Biophys Res Commun 495: 884-891 2017. pubmed/29158084
  2. Kim J, Park DY, Bae H, Park DY, Kim D, Lee CK, Song S, Chung TY, Lim DH, Kubota Y, Hong YK, He Y, Augustin HG, Oliver G, *Koh GY. Impaired angiopoietin/Tie2 signaling compromises Schlemm's canal integrity and induces glaucoma. J Clin Invest 127(10): 3877-3896, 2017. pubmed
  3. Kim J, Kim YH, Kim J, Park DY, Bae H, Lee DH, Kim KH, Hong SP, Jang SP, Kubota Y, Kwon YG, Lim DS, *Koh GY. YAP/TAZ regulates sprouting angiogenesis and vascular barrier maturation. J Clin Invest 127(9): 3441-3461, 2017. pubmed
  4. Tai-Nagara I, Yoshikawa Y, Numata N, Ando T, Okabe K, Sugiura Y, Ieda M, Takakura N, Nakagawa O, Zhou B, Okabayashi K, Suematsu M, Kitagawa Y, Bastmeyer M, Sato K, Klein R, Navankasattusas S, Li DY, Yamagishi S, *Kubota Y. Placental labyrinth formation in mice requires endothelial FLRT2–UNC5B signaling. Development 144(13): 2392-2401, 2017 [Epub ahead of print]. pubmed
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    F1000Prime.
  5. Park DY, Lee J, Kim J, Kim K, Hong S, Han S, Kubota Y, Augustin HG, Ding L, Kim JW, Kim H, He Y, Adams RH, *Koh GY. Plastic roles of pericytes in the blood-retinal barrier. Nat Commun; 8: 15296. doi: 10.1038/ncomms15296. 2017 pubmed
  6. Jang JY, Choi SY, Park I, Park DY, Choe K, Kim P, Kim YK, Lee BJ, Hirashima M, Kubota Y, Park JW, Cheng SY, Nagy A, Park YJ, Alitalo K, Shong M, *Koh GY. VEGFR2 but not VEGFR3 governs integrity and remodeling of thyroid angiofollicular unit in normal state and during goitrogenesis. EMBO Mol Med; 2017 pii: e201607341. doi: 10.15252/emmm.201607341. pubmed
  7. Yamazaki T, Nalbandian A, Uchida Y, Li W, Arnold TD, Kubota Y, Yamamoto S, Ema M, Mukouyama YS. Tissue Myeloid Progenitors Differentiate into Pericytes through TGF-β Signaling in Developing Skin Vasculature. Cell Rep; 18(12): 2991-3004, 2017. pubmed

2016

  1. Yoshikawa Y, Yamada T, Tai-Nagara I, Okabe K, Kitagawa Y, Ema M and *Kubota Y. Developmental regression of hyaloid vasculature is triggered by neurons. J Exp Med 213(7): 1175-83, 2016.pubmed
    Press release (Japanese)
    Newspaper article (Japanese)
  2. Karigane D, Kobayashi H, Morikawa T, Ootomo Y, Sakai M, Nagamatsu G, Kubota Y, Goda N, Matsumoto M, Nishimura EK, Soga T, Otsu K, Suematsu M, Okamoto S, Suda T and *Takubo K. p38α activates purine metabolism to initiate hematopoietic stem/progenitor cell cycling. Cell Stem Cell 19(2):192-204, 2016. pubmed
  3. Ozaki T, *Muramatsu R, Sasai M, Yamamoto M, Kubota Y, Fujinaka T, Yoshimine T and *Yamashita T. The P2X4 receptor is required for neuroprotection via ischemic preconditioning. Sci Rep 6:25893. doi: 10.1038/srep25893, 2016. pubmed
  4. Kim K, Kim IK, Yang JM, Lee E, Koh BI, Song S, Park J, Lee S, Choi C, Kim JW, Kubota Y, Koh GY, *Kim I. SoxF Transcription Factors Are Positive Feedback Regulators of VEGF Signaling. Circ Res 119(7): 839-52. pubmed

2015

  1. *Matsuo K, Kuroda Y, Nango N, Shimoda K, Kubota Y, Ema M, Bakiri L, Wagner EF, Takeda Y, Yashiro W and Momose A. Osteogenic capillaries orchestrate growth plate-independent ossification of the malleus. Development 142(22): 3912-20, 2015. pubmed
  2. Hong KY, Bae H, Park I, Park DY, Kim KH, Kubota Y, Cho ES, Kim H, Adams RH, Yoo OJ, *Koh GY. Perilipin+ embryonic preadipocytes actively proliferate along growing vasculatures for adipose expansion. Development 142(15): 2623-32, 2015. pubmed
  3. Zarkada G, Heinolainen K, Makinen T, Kubota Y and *Alitalo K. VEGFR3 does not sustain retinal angiogenesis without VEGFR2. Proc Natl Acad Sci USA 112(3): 761-6, 2015. pubmed

2014

  1. Tai-Nagara I, *Matsuoka S, Ariga H, *Suda T. Mortalin and DJ-1 coordinately regulate hematopoietic stem cell function through the control of oxidative stress. Blood 123(1): 41-50, 2014. pubmed
  2. *Kubota Y. Unveiling Angptl2, a rising HSC expander. Blood 124(6): 833-834 2014 (invited commentary). pubmed
  3. Okabe K, Kobayashi S, Yamad T, Kurihara T, Tai-Nagara I, Miyamoto T, Mukouyama YS, Sato TN, Suda T, Ema M and *Kubota Y. Neurons limit angiogenesis by titrating VEGF in retina. Cell 159: 584-596 2014. pubmed
    Cell preview
    Science signaling
    Youtube
    Lifescience review (Japanese)
    Scienceportal (Japanese)

2013

  1. Ikushima YM, *Arai F, Nakamra Y, Hosokawa K, Kubota Y, Hirashima M, Toyama H, *Suda T. Enhanced Angpt1/Tie2 signaling affects the differentiation and long-term repopulation ability of hematopoietic stem cells. Biochem Biophys Res Commun 2012. 430(1): 20-5, 2013. pubmed

2012

  1. Nakamura-Ishizu A, Kurihara T, Okuno Y, Ozawa Y, Kishi K, Goda N, Tsubota K, Okano H, Suda T and *Kubota Y. The formation of an angiogenic astrocyte template is regulated by the neuroretina in a HIF-1-dependent manner. Dev Biol 363(1): 106-14, 2012. pubmed
  2. Sano K, Katsuta O, Shirae S, Kubota Y, Ema M, Suda T, Nakamura M and *Hirashima M. Flt1 and Flk1 mediate regulation of intraocular pressure and their double heterozygosity causes the buphthalmia in mice Biochem Biophys Res Commun 420(2): 422-7, 2012. pubmed
  3. Takase H, Matsumoto K, Yamadera R, Kubota Y, Otsu A, Suzuki R, Ishitobi H, Mochizuki H, Kojima T, Takano S, Uchida K, Takahashi S, and *Ema M. Genome-wide identification of endothelial cell-enriched genes in the mouse embryo Blood 120(4): 914-23. 2012. pubmed
  4. Nakamura-Ishizu A, Okuno Y, Omatsu Y, Okabe K, Morimoto J, Uede T, Nagasawa T, Suda T and *Kubota Y. Extracellular matrix protein Tenascin-C is required in the bone marrow microenvironment primed for hematopoietic regeneration. Blood 119(23): 5429-5437, 2012. pubmed
  5. Okuno Y, Nakamura-Ishizu A, Otsu K, Suda T and *Kubota Y. Pathological neoangiogenesis depends on oxidative stress regulation by ATM. Nat Med 18(8): 1208–1216, 2012. pubmed
    Nature Medicine Preview
    Cell Metabolism Preview
    Lifescience review (Japanese)
  6. *Kubota Y. Tumor angiogenesis and anti-angiogenic therapy. Keio J Med. 61(2): 47-56, 2012 (invited review). pubmed

2011

  1. *Kubota Y, Takubo K, Hirashima M, Nagoshi N, Kishi K, Okuno Y, Nakamura-Ishizu A, Sano K, Murakami M, Ema M, Omatsu Y, Takahashi S, Nagasawa T, Shibuya M, Okano H and *Suda T. Isolation and function of mouse tissue resident vascular precursors marked by myelin protein zero. J Exp Med 208(5): 949-60, 2011. pubmed
  2. Okuno Y, Nakamura-Ishizu A, Kishi K, Suda T and *Kubota Y. Bone marrow-derived cells serve as pro-angiogenic macrophages but not endothelial cells in wound healing. Blood 117(19): 5264-72, 2011. pubmed
  3. Shimizu R, Okabe K, Kubota Y, Nakamura-Ishizu A, Nakajima H and *Kishi K. Sphere formation restores and confers hair-inducing capacity in cultured mesenchymal cells. Exp Dermatol 20(8): 679-81, 2011. pubmed
  4. *Kubota Y and Suda T. Vascularity of nongynecological leiomyosarcoma depends on colony-stimulating factor 1 but not on vascular endothelial growth factor. Am J Pathol 179(4): 1591-3, 2011. pubmed
  5. Zou P, Yoshihara H, Hosokawa K, Tai I, Shinmyozu K, Tsukahara F, Maru Y, Nakayama K, Nakayama KI, Suda T. p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70. Cell Stem Cell 9(3): 247-61 2011. pubmed

2010

  1. Kurihara T, Kubota Y (equally first author), Ozawa Y, Takubo K, Noda K, Simon MC, Johnson RS, Suematsu M, Tsubota K, Ishida S, Goda N, *Suda T and *Okano H. von Hippel-Lindau protein regulates transition from fetal to adult circulatory system in retina. Development 137: 1563-1571, 2010. pubmed
  2. *Iwasaki H, Arai F, Kubota Y, Dahl M and *Suda T. Endothelial protein C receptor-expressing hematopoietic stem cells reside in the perisinusoidal niche in fetal liver.　Blood 116(4): 544-53, 2010. pubmed
  3. *Takubo K, Goda N, Yamada W, Iriuchishima H, Ikeda E, Kubota Y, Shima H, Johnson RS, Hirao A, Suematsu M,* Suda T.　Regulation of the HIF-1alpha Level Is Essential for Hematopoietic Stem Cells. Cell Stem Cell 7(3): 391-402, 2010. pubmed
  4. Nakada S, Tai I, Panier S, Al-Hakim A, Iemura S, Juang YC, O'Donnell L, Kumakubo A, Munro M, Sicheri F, Gingras AC, Natsume T, Suda T, Durocher D. Non-canonical inhibition of DNA damage-dependent ubiquitination by OTUB1. Nature 466(7309): 941-6, 2010. pubmed

2009

  1. *Kubota Y, Takubo K, Shimizu T, Ohno H, Kishi K, Shibuya M, Saya H and *Suda T. M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis. J Exp Med 206: 1089-102, 2009. pubmed
  2. *Kubota Y and *Suda T. Feedback mechanism between blood vessels and astrocytes in retinal vascular development. Trends Cardiovasc Med 19: 38-43, 2009 (invited review). pubmed
  3. Morikawa S, Mabuchi Y, Kubota Y, Nagai Y, Niibe K, Hiratsu E, Suzuki S, Miyauchi-Hara C, Nagoshi N, Sunabori T, Shimmura S, Miyawaki A, Nakagawa T, Suda T, Okano H and *Matsuzaki Y. Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med 206: 2483-96, 2009. pubmed

2008

  1. *Kubota Y, Hirashima M, Kishi K, Stewart CL and *Suda T. Leukemia inhibitory factor regulates microvessel density by modulating oxygen-dependent VEGF expression in mice. J Clin Invest 118(7): 2393-2403, 2008. pubmed
  2. Kubota Y, Takubo K and *Suda T. Bone marrow long label-retaining cells reside in the sinusoidal hypoxic niche. Biochem Biophys Res Commun 366: 335-9, 2008. pubmed
  3. Nagoshi N, Shibata S, Kubota Y, Nakamura M, Nagai Y, Satoh E, Morikawa S, Okada Y, Mabuchi Y, Katoh H, Okada S, Fukuda K, Suda T, Matsuzaki Y, Toyama Y, *Okano H. Ontogeny and Multipotency of Neural Crest-Derived Stem Cells in Bone Marrow, Dorsal Root Ganglia and Whisker Pad of Adult Rodents. Cell Stem Cell 2: 392-403, 2008. pubmed

2007

  1. *Kaname T, Yanagi K, Chinen Y, Makita Y, Okamoto N, Maehara H, Owan I, Kanaya F, Kubota Y, Oike Y, Yamamoto T, Kurosawa K, Fukushima Y, Bohring A, Opitz JM, Yoshiura K, Niikawa N and Naritomi K. Mutations in CD96, a member of the immunoglobulin superfamily, cause a form of the C (Opitz Trigonocephaly) syndrome. Am J Hum Genet 81(4): 835-41, 2007.
  2. Morita K, *Miyamoto T, Fujita N, Kubota Y, Ito K, Takubo K, Miyamoto K, Ninomiya K, Suzuki T, Iwasaki R, Yagi M, Takaishi H, Toyama Y and *Suda T.　 Reactive oxygen species induce chondrocyte hypertrophy in endochondral ossification. J Exp Med 204(7): 1613-23, 2007. pubmed